The aim of this work was to develop and validate a dissolution test for ILAPRAZOLE in Tablets using spectrophotometric method. The dissolution established conditions were 0.1N HCL 900 mL for 2 hrs then transfer 900 ml of phosphate buffer pH 7.5 with 0.1% of sodium lauryl sulphate as dissolution medium, using a paddel apparatus at a rotating rate of 100 rpm. The drug release was evaluated by UV spectrophotometric method at 308 nm. The method was validated to meet requirements for a global regulatory filing. The validation included specificity, linearity, precision and accuracy.
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